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Tolmetin

Tolmetin, a.k.a. Tolectin is a nonsteroidal anti-inflammatory drug (NSAID) of the heterocyclic acetic acid derivative class.

It was developed in the 1970's, and is used to treat conditions such as osteoarthritis, Rheumatoid Arthritisplugin-autotooltip__plain plugin-autotooltip_bigRheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic severe inflammatory disease believed to affect around 1% of the global population. It primarily affects joints,which typically become warm, swollen,and painful. Pain and stiffness often worsen following rest. Most commonly, the wrists and hands are involved, with the same joints typically involved on both sides of the body.
, and Ankylosing Spondylitisplugin-autotooltip__plain plugin-autotooltip_bigAnkylosing Spondylitis

"Ankylosing spondylitis (AS) is a type of arthritis that affects the spine. AS often involves redness, heat, swelling, and pain in the spine or in the joint where the bottom of the spine (sacrum) joins the pelvic bone (ilium)."

Its mechanism of action is unclear..

The mode of action of tolmetin is not known. However, studies in laboratory animals and man have demonstrated that the anti-inflammatory action of tolmetin is not due to pituitary-adrenal stimulation. Tolmetin inhibits prostaglandin synthetase in vitro and lowers the plasma level of prostaglandin E in man. This reduction in prostaglandin synthesis may be responsible for the anti-inflammatory action. Tolmetin does not appear to alter the course of the underlying disease in man.

Source : Drugbank

Also see :Paracetamolplugin-autotooltip__plain plugin-autotooltip_bigParacetamol

"Acetaminophen (INN Paracetamol) is one of the most widely used over-the-counter antipyretic and analgesic drugs worldwide. [...] Although discovered more than 100 years ago, and used extensively for ~ 50 years, its mode of action is still unclear


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