Please register ( or log-in ) to create and edit pages

User Tools

    Please register ( or log-in ) to create and edit pages
  • Register

Site Tools


Main Menu

Main menu
[ Click categories to expand ]

Other categories

For tests only


Also see:

Content Guidelinesplugin-autotooltip__plain plugin-autotooltip_bigContent guidelines

Ideas for new topics are always welcomed, from experts and non-experts alike - if you're not sure if they'll be accepted by other editors, put them in the 'Proposed content' section for approval. The easiest way to create a new page is to use the

Registrationplugin-autotooltip__plain plugin-autotooltip_bigRegistration

At present, only registered users can create and edit articles. The registration process is very straightforward. Just click the 'Register' link at the top right of any page.

After you've registered, you'll be able to login with your password at any time…

How to edit pagesplugin-autotooltip__plain plugin-autotooltip_bigEditing pages

Once you're logged in, a grey floating 'Tool' menu at the right hand side of the screen enables access to all the main 'Content Pages' for editing. (Note: Some pages, such as the site info etc. are locked)

Like most Wikis, the site doesn't use

Importance Ratingsplugin-autotooltip__plain plugin-autotooltip_bigImportance ratings

In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

Faqplugin-autotooltip__plain plugin-autotooltip_bigFrequently Asked Questions

Q. Why the weird syntax? A. Like most Wikis, the site doesn't use HTML for formatting (security reasons etc). A guide to the special syntax can be found here. Unfortunately it can be quite confusing at first - but there's now a new 'Visual …

Newsplugin-autotooltip__plain plugin-autotooltip_bigNews

[ newest at the top ]

• Oct 2020 : A milestone of 500 unknown articles has been reached.

• Aug 2020 : Currently (beta) testing the new 'WYSIWYG' (What You See Is What You Get) page editor. It greatly simplifies the editing process, avoiding the need to learn th…

Contactsplugin-autotooltip__plain plugin-autotooltip_bigContacts

Use this form to send a message to Wikenigma . . . [ * note: all fields must be completed ]

Legalplugin-autotooltip__plain plugin-autotooltip_bigLegal

Content in general

Please note that in common with other publicly editable wikis, this website is not responsible for content posted by the public. Nevertheless, the ongoing editing process should be able to remove unsuitable content in a reasonable time. If you…


541 unknowns listed

Wikenigma supports:

plugin-autotooltip__plain plugin-autotooltip_bigDonate to Wikenigma . . .

The best way to donate is by adding new original content !

That can either be by contributing to an existing article, or by creating a new page with an as-yet-unlisted 'Known Unknown'.

Any registered user can create content.

A-Z listing
rss / xml feed
sitemap file

Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown Science

Paracetamol

One of the most widely prescribed drugs in history works by mechanisms which have not yet been agreed upon by the medical establishment. It‘s believed that paracetamol acts via more than one neurological pathway, one of which may be by inhibiting the COX-3 isoform of the COX family of enzymes. Ref. wikpedia

“The fact is, despite its ubiquity, we still don’t really understand how paracetamol works. A leading theory is that, in part, it works like aspirin and ibuprofen, by blocking enzymes known as cyclooxygenases.
These enzymes are responsible for making hormone-like compounds called prostaglandins, which trigger pain and swelling in the body as well as stimulating production of the mucous that shields our stomachs against digestive acids.” source: see below

Recent research suggests that Paracetamol has a marginal effect for pain relief - but only in around 25% of individuals - and that its beneficial action in others is due to placebo effects. However, the drug has significant side-effects (including stomach-lining damage) and overdoses each year run into 80,000 per year in the US alone.

A May 2014 cover story from New Scientist 'Cure-all no more' drew attention to a review of research that looked at people taking paracetamol to relieve chronic joint pain, examining seven studies that compared the drug with a placebo. Five of these found it to be marginally more effective, but two found no difference.

“Why are we bothering to give a drug to people that’s toxic, that has significant potential problems, when it doesn’t work?” asks Andrew Moore, an anaesthetist and director of pain research at the University of Oxford. “It’s unethical.”


    Share this page :

Importance Rating


DOKUWIKI IMPLEMENTATION DESIGN BY UNIV.ORG.UK