Depression is expected to become the leading cause of disabilities worldwide with about 20% of the population suffering from a mood disorder at least once in a lifetime (Kessler et al., 2005; de Graaf et al., 2012). Even more alarmingly, depression is characterized by high relapse rates, which increase steeply with every subsequent depressive episode, even following psychotherapy (Steinert et al., 2014). These findings underline the importance of improving existing treatments and emphasize the necessity of effective prevention instruments to interrupt this vicious circle."

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A possible treatment for Major Depressive Disorderplugin-autotooltip__plain plugin-autotooltip_bigMajor Depressive Disorder

Major Depressive Disorder (MDD), also known simply as 'depression', is a mental disorder characterized by at least two weeks of pervasive low mood.

Current estimates are that severe depression affects around 2% of the global population at any given time, currently more than 150 million. The majority of cases don't appear to have an obvious personal and/or societal cause.under review, is Repetitive Transcranial Magnetic Stimulation.

rTMS is a non-invasive brain stimulation technique, in which sequential pulses of brief magnetic fields are generated in a coil to induce electric fields in the nerve tissue underneath the coil, leading to neuronal depolarization. Recent studies suggest that it can successfully (though temporarily) alleviate severely negative mood states in some individuals.

The mechanisms by which it does so are as yet unknown.

See Repetitive transcranial magnetic stimulation modulates the impact of a negative mood induction in Soc Cogn Affect Neurosci. 2017 Apr; 12(4): 526–533.