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Content Guidelinesplugin-autotooltip__plain plugin-autotooltip_bigContent guidelines

Ideas for new topics are always welcomed, from experts and non-experts alike - if you're not sure if they'll be accepted by other editors, put them in the 'Proposed content' section for approval. The easiest way to create a new page is to use the

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At present, only registered users can create and edit articles. The registration process is very straightforward. Just click the 'Register' link at the top right of any page.

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How to edit pagesplugin-autotooltip__plain plugin-autotooltip_bigEditing pages

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In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

Faqplugin-autotooltip__plain plugin-autotooltip_bigFrequently Asked Questions

Q. Why the weird syntax? A. Like most Wikis, the site doesn't use HTML for formatting (security reasons etc). A guide to the special syntax can be found here. Unfortunately it can be quite confusing at first - but there's now a new 'Visual …

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• Oct 2020 : A milestone of 500 unknown articles has been reached.

• Aug 2020 : Currently (beta) testing the new 'WYSIWYG' (What You See Is What You Get) page editor. It greatly simplifies the editing process, avoiding the need to learn th…

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538 unknowns listed

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Reboxetine

Reboxetine, sold under the brand name Edronax, is a drug marketed as a treatment for Major Depressive Disorderplugin-autotooltip__plain plugin-autotooltip_bigMajor Depressive Disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of pervasive low mood.

Current estimates are that severe depression affects around 2% of the global population at any g…
, Attention-Deficit / Hyperactivity Disorder (ADHD)plugin-autotooltip__plain plugin-autotooltip_bigAttention-Deficit / Hyperactivity Disorder (ADHD)

Attention deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type. It is characterized by problems paying attention, excessive activity, or difficulty controlling behavior which is not …
, and Panic Disorder amongst others

It is said to work as a norepinephrine reuptake inhibitor (NRI) with special sensitivity for the norepinephrine transporter (NET).

Like Fluoxetineplugin-autotooltip__plain plugin-autotooltip_bigFluoxetine

Trade names Prozac™, Sarafem™, Fontex™ etc.

Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) used in the treatment of major depression, OCD etc.

SSRIs are believed to act by inhibiting the reuptake of serotonin after being released in the brai…
, an exact mechanism of action has not been found.

Despite widespread efforts to understand the mechanisms of action of antidepressant drugs, the requisite changes in neural function that underlie their therapeutic effects remain unclear. […] However, taken together with previous findings that chronic administration of fluoxetine also results in enhanced activation of LC neurons to a stressor (Page and Abercrombie 1997), our present findings suggest a possible shared mechanistic link between two distinct classes of antidepressant compounds. The exact nature of the mechanism remains unclear but it is likely to rely on the sensitivity of the noradrenergic system to stressors. Source: Nature

Note: A 2010 German study determined that Reboxetine works no better than a placebo.


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