Primidone (a.k.a. Mysoline, Lepsiral, Mysoline, Resimatil and others) is a commonly prescribed anticonvulsant (barbiturate) drug used to treat, and other disorders. It has more than 2 million yearly prescriptions in the US alone.
It was first approved in the US in 1954, and since then, despite more than 60 years of medical research, its precise mechanism of action is still unknown.
It has been suggested that it works via interactions with voltage-gated sodium channels which inhibit high-frequency repetitive firing of action potentials in nerve cells. And that its breakdown products (as it's metabolised) may be responsible for its action.
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