Restless legs syndrome, also known as Willis-Ekbom disease, is a common condition of the nervous system that causes an overwhelming and irresistible urge to move the legs. Estimates are that around 10% of people suffer from RLS at some stage in their lives. It often occurs during sleeping hours and can cause severe insomnia. In the majority of cases there's no obvious cause (i.e. it's termed idiopathic).
RLS can be triggered (or exacerbated) by other medical problems, pregnancy, or by medications, drugs, etc.
Further reading NHS, UK
Note: One of the prominent drugs used to treat RLS,provides some relief in some patients - by an as yet unknown mechanism.
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