User Tools

    To create and edit articles, please register and log-in

Main Menu : categories & index etc.

Main menu
Click categories to expand

A-Z listingplugin-autotooltip__plain plugin-autotooltip_bigA-Z listing

This is an alphabetical index of all content pages.

Other categories



Also see

Importance Ratings
Curator's rationale
AI Policy

Twitter feed 𝕏

Feeds + s.e.o. etc.
rss / xml feed
sitemap file
A-Z listing (archived)

Indexed under : Medicine / Diseases / M - Q

Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown


Osteoarthritis (OA) is considered a complex multifactorial disease of weight-bearing joints, with extensive psychosocial impact. The etiology of primary OA remains unknown and the molecular and cellular mechanisms of OA initiation and progression are not fully elucidated.

Source : Osetoarthritis and Cartilage Journal Volume 29, ISSUE 1, P6-7, January 01, 2021

As the paper cited above notes, although it has been known for many years that general 'wear and tear' damage, and specific injury, can lead to the development of osteoarthritis, the exact biological pathways are currently unknown.

The condition results in the breakdown of joint cartilage and underlying bone. It's extremely common - for example, the lifetime risk of an individual developing osteoarthritis of the knee is currently estimated at 46% ( source : American College of Rheumatology. )

To date, a number of pathways implicated in various aspects of OA, such as inflammation, apoptosis, chondrogenesis, degeneration, and circadian clock, have been targeted for treatment purposes.

Further info US NIH National Institute on Aging

A 2023 study suggests that a possible contributing factor could be imbalanced changes in the ubiquitous mammalian Synovial Fluid (SF), the joint lubricant which contains biomolecules including hyaluronan, lubricin, and phospholipids.

The imbalances, say the research team, could lead to early wear in the joints. See : Biointerphases Volume 18, Issue 2

Also see : Rheumatoid Arthritisplugin-autotooltip__plain plugin-autotooltip_bigRheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic severe inflammatory disease believed to affect around 1% of the global population. It primarily affects joints, typically resulting in warm, swollen, painful joints. Pain and stiffness often worsen following r…

Importance Rating

    Please share this page to help promote Wikenigma !

Dear reader : Do you have any suggestions for the site's content?

Ideas for new topics, and suggested additions / corrections for older ones, are always welcome.

If you have skills or interests in a particular field, and have suggestions for Wikenigma, get in touch !

Or, if you'd like to become a regular contributor . . . request a login password. Registered users can edit the entire content of the site, and also create new pages.

( The 'Notes for contributors' section in the main menu has further information and guidelines etc.)

Automatic Translation

You are currently viewing an auto-translated version of Wikenigma

Please be aware that no automatic translation engines are 100% accurate, and so the auto-translated content will very probably feature errors and omissions.

Nevertheless, Wikenigma hopes that the translated content will help to attract a wider global audience.

Show another (random) article

Further resources :