Kyrle disease is a relatively rare 'perforating' skin condition which leads to the formation of multiple large (up to 1.5cm) skin papules that have central keratin plugs. It usually affects the legs, but can also erupt in other areas. It was first described in 1916. The cause is currently unknown.
The disease is 'associated' with, liver disease, and especially with kidney disease. The prevalence in kidney dialysis patients being around 10%.
The exact etiology of Kyrle disease is unknown. Many theories have been proposed in the literature including infectious, abnormal keratinization, defective differentiation of the epidermis and dermo-epidermal junction, elevated serum and tissue concentrations of fibronectin, uremia (renal failure), and hyperphosphatemia (diabetes mellitus). The high incidence of systemic disease associated with the development of Kyrle disease suggests an underlying systemic disorder as the main etiology.
Source : Europe PMC, StatPearls
More information DermNet NZ
Ideas for new topics, and suggested additions / corrections for older ones, are always welcome.
If you have skills or interests in a particular field, and have suggestions for Wikenigma, get in touch !
Or, if you'd like to become a regular contributor . . . request a login password. Registered users can edit the entire content of the site, and also create new pages.
( The 'Notes for contributors' section in the main menu has further information and guidelines etc.)
You are currently viewing an auto-translated version of Wikenigma
Please be aware that no automatic translation engines are 100% accurate, and so the auto-translated content will very probably feature errors and omissions.
Nevertheless, Wikenigma hopes that the translated content will help to attract a wider global audience.