A detailed explanation of the factors which regulate cell size (i.e. the size to which cells grow) has not yet been found. Since (most) cells stop growing when they reach a specific size, it's suggested that there must be some feedback mechanism to restrict growth beyond that point.
The existence of a â€śsize controlâ€ť is well known and the control has been studied for a long time, but it has been remarkably resistant to molecular analysis. The attainment of a critical size triggers the periodic events of the cycle such as the S period and mitosis. This control acts as a homeostatic effector that maintains a constant â€śaverageâ€ť cell size at division through successive cycles in a growing culture. It is a vital link coordinating cell growth with periodic events of the cycle. A size control is present in all the systems and appears to operate near the start of S or of mitosis when the cell has reached a critical size, but the molecular mechanism by which size is measured remains both obscure and a challenge.â€ś
Source : Growth dung the cell cycle (paywalled)International Review of Cytology, Volume 226, 2003, Pages 165-258
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