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Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown


Metformin, sold under the brand names of Bolamyn, Diagemet, Glucient, Glucophage, Metabet, Obimet, Gluformin, Dianben, Diabex, Diaformin, Metsol, Siofor, Metfogamma (and many others) is a prescription-only medication used in the treatment of Type 2 Diabetes.

It's been in use worldwide since 1957, and the prescription rates are now around 78 million in the US alone. It can reduce a diabetic person's (excess) blood glucose by 30%.

It was originally derived from the French lilac or Goat's rue (Galega officinalis) which has been used in herbal remedies for several centuries.

Its mechanism of action is unknown. There are multiple proposals as to how it might operate - including as an appetite suppressant. See Wikipedia

Metformin is currently being investigated, with promising results, as a treatment for :
Alzheimer's diseaseplugin-autotooltip__plain plugin-autotooltip_bigAlzheimer's disease

"Alzheimer’s disease is a chronic progressive neuro-degenerative disorder characterised by three primary groups of symptoms. The first group (cognitive dysfunction) includes memory loss, language difficulties, and executive dysfunction (that is, loss of higher level planning and intellectual coordination skills). The second group comprises psychiatric symptoms and behavioural disturbances — for example, depression, hallucinations, delusions, agitation — collectively termed …
Parkinson's diseaseplugin-autotooltip__plain plugin-autotooltip_bigParkinson's disease

Also known as Parkinson disease, Parkinson's, idiopathic Parkinsonism, primary Parkinsonism, PD, or paralysis agitans - is a degenerative disorder of the central nervous system resulting from the death of dopamine-containing cells in the
Lupusplugin-autotooltip__plain plugin-autotooltip_bigLupus

"Systemic lupus erythematosus, also called SLE or lupus, is a disease of the immune system that causes the immune system to attack tissues in various parts of the body. The cause of lupus is unknown. Finding the cause is the object of major research efforts.
Long Covidplugin-autotooltip__plain plugin-autotooltip_bigCovid-19

Editor's note : Because of the intense, ongoing, global research efforts related to Covid-19, it's difficult to get an accurate picture of the unknown factors. Here are some of the many as-yet-unanswered questions Why does the virus have much more serious effects in older people?
There is no explanation for its apparent efficacy in treating any of these conditions.

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