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Content Guidelinesplugin-autotooltip__plain plugin-autotooltip_bigContent guidelines

Ideas for new topics are always welcomed, from experts and non-experts alike - if you're not sure if they'll be accepted by other editors, put them in the 'Proposed content' section for approval. The easiest way to create a new page is to use the

Registrationplugin-autotooltip__plain plugin-autotooltip_bigRegistration

At present, only registered users can create and edit articles. The registration process is very straightforward. Just click the 'Register' link at the top right of any page.

After you've registered, you'll be able to login with your password at any time…

How to edit pagesplugin-autotooltip__plain plugin-autotooltip_bigEditing pages

Once you're logged in, a grey floating 'Tool' menu at the right hand side of the screen enables access to all the main 'Content Pages' for editing. (Note: Some pages, such as the site info etc. are locked)

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Importance Ratingsplugin-autotooltip__plain plugin-autotooltip_bigImportance ratings

In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

Faqplugin-autotooltip__plain plugin-autotooltip_bigFrequently Asked Questions

Q. Why the weird syntax? A. Like most Wikis, the site doesn't use HTML for formatting (security reasons etc). A guide to the special syntax can be found here. Unfortunately it can be quite confusing at first - but there's now a new 'Visual …

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• Oct 2020 : A milestone of 500 unknown articles has been reached.

• Aug 2020 : Currently (beta) testing the new 'WYSIWYG' (What You See Is What You Get) page editor. It greatly simplifies the editing process, avoiding the need to learn th…

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Content in general

Please note that in common with other publicly editable wikis, this website is not responsible for content posted by the public. Nevertheless, the ongoing editing process should be able to remove unsuitable content in a reasonable time. If you…


541 unknowns listed

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Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown Science

Lithium (treatment for bipolar disorder)

Lithium, normally in the form of lithium carbonate (Li2CO3) is widely recognised as the 'gold standard' prescribed drug for treating bipolar disorder, depression and mania.

In widespread use since the early 1970s, lithium carbonate was the first FDA approved drug for 'mood control'.

However, despite more than forty years of intense research, and millions of treated patients - “The precise mechanism of action of Li+ as a mood-stabilizing agent is currently unknown.” Source: Wikipedia

Further, for reasons that are also unknown, therapeutic lithium has little or no effect on some individuals :

“Lithium is generally regarded as the first-line agent for the management of BP, although it does not work for everyone. For instance, Geddes and colleagues performed a meta-analysis of five randomized controlled trials comparing prophylactic lithium therapy with placebo in BP and found that lithium is more effective than placebo in preventing recurrence of illness, with 60% in the lithium group remaining well over 1–2 years compared with 40% in the placebo group.”

source: External Predictors of Lithium Response in Bipolar Disorder

Also see Lamotrigineplugin-autotooltip__plain plugin-autotooltip_bigLamotrigine

Lamotrigine is used as an anticonvulsant and mood stabilizer. Currently prescribed in cases of epilepsy, Lennox–Gastaut syndrome and bipolar disorder. Its active biochemical pathways are not known. more info at Wikipedia

"“The action mechanisms underlying…
and Ketamineplugin-autotooltip__plain plugin-autotooltip_bigKetamine (treatment for depression)

The use of Ketamine to treat depression was formally investigated in a 2006 report for JAMA Psychiatry. A team based at the US National Institute of Mental Health (NIMH) in Bethesda, Maryland, found that :

"“Robust and rapid anti…
and Major Depressive Disorderplugin-autotooltip__plain plugin-autotooltip_bigMajor Depressive Disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of pervasive low mood.

Current estimates are that severe depression affects around 2% of the global population at any g…


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