Please register ( or log-in ) to create and edit pages

User Tools

    Please register ( or log-in ) to create and edit pages
  • Register

Site Tools


Main Menu

Main menu
[ Click categories to expand ]

Other categories

For tests only


Also see:

Content Guidelinesplugin-autotooltip__plain plugin-autotooltip_bigContent guidelines

Ideas for new topics are always welcomed, from experts and non-experts alike - if you're not sure if they'll be accepted by other editors, put them in the 'Proposed content' section for approval. The easiest way to create a new page is to use the

Registrationplugin-autotooltip__plain plugin-autotooltip_bigRegistration

At present, only registered users can create and edit articles. The registration process is very straightforward. Just click the 'Register' link at the top right of any page.

After you've registered, you'll be able to login with your password at any time…

How to edit pagesplugin-autotooltip__plain plugin-autotooltip_bigEditing pages

Once you're logged in, a grey floating 'Tool' menu at the right hand side of the screen enables access to all the main 'Content Pages' for editing. (Note: Some pages, such as the site info etc. are locked)

Like most Wikis, the site doesn't use

Importance Ratingsplugin-autotooltip__plain plugin-autotooltip_bigImportance ratings

In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

Faqplugin-autotooltip__plain plugin-autotooltip_bigFrequently Asked Questions

Q. Why the weird syntax? A. Like most Wikis, the site doesn't use HTML for formatting (security reasons etc). A guide to the special syntax can be found here. Unfortunately it can be quite confusing at first - but there's now a new 'Visual …

Newsplugin-autotooltip__plain plugin-autotooltip_bigNews

[ newest at the top ]

• Oct 2020 : A milestone of 500 unknown articles has been reached.

• Aug 2020 : Currently (beta) testing the new 'WYSIWYG' (What You See Is What You Get) page editor. It greatly simplifies the editing process, avoiding the need to learn th…

Contactsplugin-autotooltip__plain plugin-autotooltip_bigContacts

Use this form to send a message to Wikenigma . . . [ * note: all fields must be completed ]

Legalplugin-autotooltip__plain plugin-autotooltip_bigLegal

Content in general

Please note that in common with other publicly editable wikis, this website is not responsible for content posted by the public. Nevertheless, the ongoing editing process should be able to remove unsuitable content in a reasonable time. If you…


538 unknowns listed

Wikenigma supports:

plugin-autotooltip__plain plugin-autotooltip_bigDonate to Wikenigma . . .

The best way to donate is by adding new original content !

That can either be by contributing to an existing article, or by creating a new page with an as-yet-unlisted 'Known Unknown'.

Any registered user can create content.

A-Z listing
rss / xml feed
sitemap file

Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown Science

Intraoperative Awareness

Intraoperative Awareness (a.k.a. Anesthesia awareness) occurs as a complication during general anesthesia, where the intended state of complete unconsciousness is not maintained throughout the whole procedure.

“The incidence of this anesthesia complication is variable and seems to affect 0.2% to 0.4% of patients according to the surgical setting carried out. This variation reflects the surgical setting as well as the physiological state of the patient. Thus, the incidence is 0.2% in general surgery, about 0.4% during caesarean section, between 1 and 2% during cardiac surgery and between 10% and 40% for anesthesia of the traumatized.”
Source: Wikipedia
The causes of intraoperative awareness are as yet unknown, and the problem may be multifactorial. At least 4 broad categories of causes are plausible. First, unexpected patient-specific variability in dose requirements of anesthetic drugs may be a result of altered expression or function of target receptors. Second, patients may be unable to tolerate a sufficient dose of anesthetic because of low physiologic reserves related to factors such as poor cardiac function or severe hypovolemia. Third, physiologic characteristics that would indicate the need for a dose change may be masked by factors such as use of β-adrenergic receptor blockers or presence of a pacemaker. Fourth, intended drug delivery systems may be compromised by events such as equipment malfunction or misuse.”

Source: Awareness during anesthesia Beverley A. Orser, C. David Mazer and Andrew J. Baker, CMAJ January 15, 2008 178 (2) 185-188.


Also see :General Anaestheticsplugin-autotooltip__plain plugin-autotooltip_bigGeneral Anaesthetics

A general anaesthetic is a drug that brings about a reversible loss of consciousness. In formal use since 1842 - with the first public demonstration of ether to carry out surgery. (Though it's likely that alcohol, another chemical classed as an an…


    Share this page :


DOKUWIKI IMPLEMENTATION DESIGN BY UNIV.ORG.UK