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Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown

Colchicine

Colchicine is an anti-inflammatory medication used to treat Gout and Behçet's diseaseplugin-autotooltip__plain plugin-autotooltip_bigBehçet's disease

"Behçet’s Syndrome (also known as Behçet’s Disease or, simply, Behçet’s) is a chronic condition resulting from disturbances in the body’s immune system. This system, which normally protects the body against infections by producing controlled inflammat…
. Sold under the brand names Colcrys, Mitigare, Gloperba and many others.

It was originally isolated from a herbal remedy - the Autumn Crocus plant - in use for at least 3,000 years to reduce joint swelling.

There are currently more than 2 million prescriptions per year in the US alone, and it's now a generic medicine in the UK.

There are at least seven different theories currently under investigation to try to explain how it works. It's suggested that it :

  • inhibits microtubule polymerization by binding to its constitutive protein, tubulin
  • inhibits mitosis, as availability of tubulin is essential to mitosis,
  • inhibits activation and migration of neutrophils to sites of inflammation
  • interferes with the inflammasome complex found in neutrophils and monocytes that mediate interleukin-1β activation, a component of inflammation
  • inhibits superoxide anion production in response to urate crystals
  • interrupts mast cell and lysosome degranulation
  • inhibits release of glycoproteins that promote chemotaxis from synovial cells and neutrophils

Source : Wikpedia


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