“Artificial sweetener consumption is widely believed to be an effective method to limit caloric intake and maintain glycemic control. However, there is no evidence from long-term prospective analyses that the consumption of artificial sweeteners result in benefits in terms of weight loss and glycemic control (Swithers 2013). In fact, accumulating evidence now points to the opposite; that such products may precipitate metabolic derangements in susceptible individuals (Nettleton et al. 2016).” Source: Artificially sweetened taste of insulin resistance? Editorial, journal of Applied Physiology, Nutrition and Metabolism, July 2016.
Several research projects have found that artificial sweeteners (especially Aspartame) can cause glucose intolerance. Especially puzzling because users of the sweeteners tend to consume less natural sugars (sucrose + fructose). There is currently no known explanation.