Neurofibrillary tangles (which are technically described as 'aggregates of hyperphosphorylated tau protein') are commonly known as a primary marker of. They are also prevalent in numerous other diseases - generally known as tauopathies. Little is known about their exact relationship to the different pathologies.
They are currently controversial because it's not known if they are causing disease, or simply a symptom of it.
Neurofibrillary tangles are formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate, or group, in an insoluble form. (These aggregations of hyperphosphorylated tau protein are also referred to as PHF, or â€śpaired helical filamentsâ€ť). The precise mechanism of tangle formation is not completely understood, and it is still controversial whether tangles are a primary causative factor in disease or play a more peripheral role.
Source : Wikipedia
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