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Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown

Non-celiac gluten sensitivity (NCGS)

Non-celiac gluten sensitivity (NCGS) is currently defined as : “a clinical entity induced by the ingestion of gluten leading to intestinal and/or extraintestinal symptoms that improve once the gluten-containing foodstuff is removed from the diet, and celiac disease and wheat allergy have been excluded”.

It was first described in 1976. Some studies estimate it to be the most common form of the gluten-related disorders - with incidence rates of up to 13% of the (Western) population.

The cause is unknown - though there is speculation that it's an immune-system malfunction of some kind. Some research groups maintain that there is not enough evidence to class NCGS as a distinct clinical disorder.

“Currently there is an absence of any reliable biomarkers, therefore, NCGS remains a diagnosis of exclusion.”
See : Systematic review: noncoeliac gluten sensitivity Alimentary Pharmacology & Therapeutics, Volume 41, Issue 9 p. 807-820

Also see : Irritable bowel syndrome (IBS)plugin-autotooltip__plain plugin-autotooltip_bigIrritable bowel syndrome (IBS)

"“The most common condition seen in gastrointestinal outpatient clinics is irritable bowel syndrome (IBS), which has a prevalence rate of 14-24% in women and 5-19% in men. [...] There is no known structural or anatomical explanation that…


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