Non-celiac gluten sensitivity (NCGS) is currently defined as : â€śa clinical entity induced by the ingestion of gluten leading to intestinal and/or extraintestinal symptoms that improve once the gluten-containing foodstuff is removed from the diet, and celiac disease and wheat allergy have been excludedâ€ť.
It was first described in 1976. Some studies estimate it to be the most common form of the gluten-related disorders - with incidence rates of up to 13% of the (Western) population.
The cause is unknown - though there is speculation that it's an immune-system malfunction of some kind. Some research groups maintain that there is not enough evidence to class NCGS as a distinct clinical disorder.
Currently there is an absence of any reliable biomarkers, therefore, NCGS remains a diagnosis of exclusion.â€ś
See : Systematic review: noncoeliac gluten sensitivity Alimentary Pharmacology & Therapeutics, Volume 41, Issue 9 p. 807-820
Also see :
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