Hodgkin lymphoma is caused by a change in the DNA of a B-cell lymphocyte. This mutation causes a large number of abnormal and oversized B cells to accumulate in the lymphatic system, and, over time, spread to other organs. It is not clear what causes DNA mutation.
Various factors have been identified which lead to increased risk of developing Hodgkin lymphoma (HL). They include : age - being male - family history of HL - previous infection with the Epstein Barr virus.
But in the majority of cases the trigger is unknown.
More Information about HL US NIH National Cancer Institute
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