Main menu
Click categories to expand
A-Z listingplugin-autotooltip__plain plugin-autotooltip_bigA-Z listing
This is an alphabetical index of all content pages.
Other categories
Utilities
Also see
Importance Ratings
News
Legal
Donate/Sponsor
Curator's rationale
AI Policy
Twitter feed ð•
Feeds + s.e.o. etc.
rss / xml feed 
sitemap file
A-Z listing (archived)
Calpainopathy (a.k.a. LGMDR1) is the most common type of autosomal recessive limb-girdle muscular dystrophy (LGMD) It affects the muscles of the hip girdle and shoulder girdle.
Symptoms usually appear between the ages of 8 and 15. In severe cases, patients lose the ability to walk 10 - 20 years after symptoms first show.
It is linked to a mutation in the gene CAPN3, but the pathophysiology - the mechanism which leads to the disease - is unknown. To date, there is no effective treatment for this disease.
A 2019 research paper
in the International Journal of Molecular Sciences suggests that it may be related to faulty calcium regulation - “Ca2+ dysregulation seems to play a central pathogenic role in this disease.â€
Ideas for new topics, and suggested additions / corrections for older ones, are always welcome.
If you have skills or interests in a particular field, and have suggestions for Wikenigma, get in touch !
Or, if you'd like to become a regular contributor . . . request a login password. Registered users can edit the entire content of the site, and also create new pages.
( The 'Notes for contributors' section in the main menu has further information and guidelines etc.)
You are currently viewing an auto-translated version of Wikenigma
Please be aware that no automatic translation engines are 100% accurate, and so the auto-translated content will very probably feature errors and omissions.
Nevertheless, Wikenigma hopes that the translated content will help to attract a wider global audience.
DOKUWIKI IMPLEMENTATION DESIGN BY UNIV.ORG.UK NOVEMBER 2023