User Tools

    To create and edit articles, please register and log-in

Main Menu : categories & index etc.

Main menu
Click categories to expand

A-Z listingplugin-autotooltip__plain plugin-autotooltip_bigA-Z listing

This is an alphabetical index of all content pages.

Other categories



Also see

Importance Ratings
Curator's rationale
AI Policy

Twitter feed 𝕏

Feeds + s.e.o. etc.
rss / xml feed
sitemap file
A-Z listing (archived)

Indexed under : Medicine / Diseases / A - F

Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown


Cachexia (CC) is the name given to weight-loss (mostly muscle, but sometimes also including fat) associated with cancer and a long list of other severe diseases. It's thought to affect as many as 70 million people worldwide.

It's been found to be linked to abnormal increases in certain cytokines (cell-signalling peptide proteins) circulating in the bloodstream. These specific cytokines trigger protein breakdown of the muscle fibres.

The exact mechanisms by which so many severe diseases cause the over-production of the cytokines - and possible other bio-pathways - is not known.

The mechanisms underlying the development of cachexia are not well understood. However, these mechanisms are gradually being elucidated through recent progress using biochemical and biological analyses. For example, the involvement of proteolysis-inducing factor (PIF), which is released from tumors and reflects abnormalities of the
neuroendocrine system, is gradually being revealed. The activation of inflammatory cytokines resulting from the interactions between the cancer cells and host cells varies.

Anticancer Research, 43, 511-521, 2023

Note: Cachexia is a separate syndrome from Sarcopeniaplugin-autotooltip__plain plugin-autotooltip_bigSarcopenia

"Sarcopenia, the decline in skeletal muscle mass and function without any underlying disease, is a major contributor to physical disability, poor quality of life, and death among the elderly [...] 40%–50% of individuals over 80 years of age suffer from thi…
- which isn't triggered by other underlying diseases. The symptoms appear substantially similar though, and the two syndromes often occur together.

    Please share this page to help promote Wikenigma !

Dear reader : Do you have any suggestions for the site's content?

Ideas for new topics, and suggested additions / corrections for older ones, are always welcome.

If you have skills or interests in a particular field, and have suggestions for Wikenigma, get in touch !

Or, if you'd like to become a regular contributor . . . request a login password. Registered users can edit the entire content of the site, and also create new pages.

( The 'Notes for contributors' section in the main menu has further information and guidelines etc.)

Automatic Translation

You are currently viewing an auto-translated version of Wikenigma

Please be aware that no automatic translation engines are 100% accurate, and so the auto-translated content will very probably feature errors and omissions.

Nevertheless, Wikenigma hopes that the translated content will help to attract a wider global audience.

Show another (random) article

Further resources :