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Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown Science

Intrinsically disordered proteins

Before year 2000, it was generally assumed that the way in which proteins 'folded' was the sole key to understanding their function in life-systems. (See :Protein structuringplugin-autotooltip__plain plugin-autotooltip_bigProtein structuring

Genes set the order that amino acids (the chemical building blocks of proteins) appear in the proteins which they code for. But, working from the gene, the form which the protein's 3-D structure will take cannot as yet be predicted. The extremely co…
). Since then, it has now been shown that many proteins do not entirely 'fold up' - leaving large sections of the protein chain as random coils. This can profoundly affect the way in which they function and influence cellular systems.

It's currently estimated that around 33% of proteins in cells which have a nucleus are 'Intrinsically Disordered'

It's largely unknown how the disordered sections might influence the proteins' function. Especially as, being unconstained, they can re-organise and presumably operate in differnt ways at different times.

See: Wikipedia


Also see : Protein structuringplugin-autotooltip__plain plugin-autotooltip_bigProtein structuring

Genes set the order that amino acids (the chemical building blocks of proteins) appear in the proteins which they code for. But, working from the gene, the form which the protein's 3-D structure will take cannot as yet be predicted. The extremely co…
and Protein Knottingplugin-autotooltip__plain plugin-autotooltip_bigProtein Knotting

Note: This article is an extension of the Protein Folding Problem

"“Knotting in proteins was once considered exceedingly rare. However, systematic analyses of solved protein structures over the last two decades have demonstrated the existence of man…


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