Before year 2000, it was generally assumed that the way in which proteins 'folded' was the sole key to understanding their function in life-systems. (See :). Since then, it has been shown that many proteins do not entirely 'fold up' - leaving large sections of the protein chain as random coils. This can profoundly affect the way in which they function and influence cellular systems.
It's currently estimated that around 33% of proteins found in cells that have a nucleus are 'Intrinsically Disordered'
It's largely unknown how the disordered sections might influence the proteins' function. Especially as, being unconstrained, they can re-organise and presumably operate in different ways at different times.
Also see :and
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