Please register and log-in to create and edit pages

User Tools

    Please register and log-in to create and edit pages

Site Tools


Main Menu

Main menu
Click categories to expand

Other categories


A-Z listingplugin-autotooltip__plain plugin-autotooltip_bigA-Z listing

This is an alphabetical index of all content pages.


Also see

Importance Ratingsplugin-autotooltip__plain plugin-autotooltip_bigImportance ratings

In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

Newsplugin-autotooltip__plain plugin-autotooltip_bigNews

[ newest at the top ]

• Mar. 2021 : Many thanks to the The British Library, which has now begun permanently archiving the contents of Wikenigma.

• Jan. 2021 : A milestone of 600 unknown articles has been reached.

• Oct. 2020 : A milestone of 500 unknown article…

Contactsplugin-autotooltip__plain plugin-autotooltip_bigContacts

Use this form to send a message to Wikenigma . . . [ * note: all fields must be completed ]

Legalplugin-autotooltip__plain plugin-autotooltip_bigLegal

Content in general

Please note that in common with other publicly editable wikis, this website is not responsible for content posted by the public. Nevertheless, the ongoing editing process should be able to remove unsuitable content in a reasonable time. If you…

Donate/Sponsorplugin-autotooltip__plain plugin-autotooltip_bigDonate to Wikenigma . . .

The best way to donate is by adding new original content !

That can either be by contributing to an existing article, or by creating a new page with an as-yet-unlisted 'Known Unknown'.

Any registered user can create content.

Registerplugin-autotooltip__plain plugin-autotooltip_bigRegistration

At present, only registered users can create and edit articles.

If you'd like to register as a contributor, please request a password.

When filling in the form, make sure you supply a valid e-mail address, as the login password will be sent to that addre…


Wikenigma supports:


Utilities
rss / xml feed
sitemap file
A-Z listing (archived)plugin-autotooltip__plain plugin-autotooltip_bigA-Z listing (archived)

This is an older, partial A-Z listing intended for search engines only.

Last updated : March 2021

For an up-to-date list see A-Z listing in the Main Menu

Abracadabra etymology

Acamprosate

Acrocyanosis

Acupuncture

Attention-Deficit / Hypera…

Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown Science

Neuromelanin

“Neuromelanin (NM) is a dark insoluble polymer pigment produced in specific populations of catecholaminergic neurons in the brain. Humans have the largest amount of NM, which is present in lesser amounts in other primates, and totally absent in many other species. However, the biological function remains unknown, although human NM has been shown to efficiently bind transition metals such as iron, as well as other potentially toxic molecules. Therefore, it may play crucial roles in apoptosis and the related Parkinson's disease.”
“Dark pigments in the substantia nigra were first described in 1838 by Purkyně,and the term neuromelanin was proposed in 1957 by Lillie, though it has been thought to serve no function until recently. It is now believed to play a vital role in preventing cell death in certain parts of the brain. It has been linked to Parkinson's disease and because of this possible connection, neuromelanin has been heavily researched in the last decade.”

Source Wikipedia

New research (2020) suggests that Neuromelanin (NM) may be playing a role as “a very efficient quencher for toxic molecules”. At the same time, however, an excessive build-up of NM in brain tissue can be also be toxic :

Thus, the paradox of NM is that its greatest virtue is its worst defect. NM can play either a cytoprotective or a neurotoxic role depending on its cellular and extracellular context and the load that carries.

See: The Neuromelanin Paradox and Its Dual Role in Oxidative Stress and Neurodegeneration Antioxidants Journal, Volume 10, Issue 1.


    Share this page :

X

Dear reader : Do you have any suggestions for the site's content?

Ideas for new topics, and suggested additions / corrections for old ones, are always welcome.

If you have skills or interests in a particular field, and have suggestions for Wikenigma, get in touch !


Or, if you'd like to become a regular contributor . . . request a login password. Registered users can edit the entire content of the site, and also create new pages.

( The 'Notes for contributors' section in the main menu has further information and guidelines etc.)

Show another (random) page

DOKUWIKI IMPLEMENTATION DESIGN BY UNIV.ORG.UK MARCH 2021