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Content Guidelinesplugin-autotooltip__plain plugin-autotooltip_bigContent guidelines

Ideas for new topics are always welcomed, from experts and non-experts alike - if you're not sure if they'll be accepted by other editors, put them in the 'Proposed content' section for approval. The easiest way to create a new page is to use the

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At present, only registered users can create and edit articles. The registration process is very straightforward. Just click the 'Register' link at the top right of any page.

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How to edit pagesplugin-autotooltip__plain plugin-autotooltip_bigEditing pages

Once you're logged in, a grey floating 'Tool' menu at the right hand side of the screen enables access to all the main 'Content Pages' for editing. (Note: Some pages, such as the site info etc. are locked)

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Importance Ratingsplugin-autotooltip__plain plugin-autotooltip_bigImportance ratings

In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

Faqplugin-autotooltip__plain plugin-autotooltip_bigFrequently Asked Questions

Q. Why the weird syntax?

A. Like most Wikis, the site doesn't use HTML for formatting (security reasons etc). A guide to the special syntax can be found here. Unfortunately it can be quite confusing at first - but there's now a new 'Visual E…

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• Oct 2020 : A milestone of 500 unknown articles has been reached.

• Aug 2020 : Currently (beta) testing the new 'WYSIWYG' (What You See Is What You Get) page editor. It greatly simplifies the editing process, avoiding the need to learn the…

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Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown Science

Microgravity Immune Suppression

“Spaceflight causes alterations in human immunity, a finding which has been well documented immediately following spaceflight. Limited in-flight studies have also confirmed that to some degree immunity is compromised during spaceflight. A comprehensive understanding of the nature of these immune changes is lacking.”
Source: Stress Challenges and Immunity in Space pp 259-275

Currently, astronauts returning from says at the International Space Station are routinely quarantined until their immune system has recovered sufficiently.

“Numerous studies have indicated that spaceflight results in dysregulation of the human immune system. This phenomenon has been well documented following flight, where landing and readaptation are significant stressors. More recent data, particularly studies onboard ISS, indicate that this phenomenon persists for the duration of a 6-month orbital spaceflight. Persistent decrements in the function of specific innate or adaptive immune cells, or alterations in cytokine production profiles, could result in clinical risk to crewmembers participating in exploration-class space missions.”
Source: Stress Challenges and Immunity in Space pp 205-220

There is as yet no (agreed) explanation as to why the human immune system becomes suppressed in microgravity environments.


Also see : Apollo Syndromeplugin-autotooltip__plain plugin-autotooltip_bigApollo Syndrome

A 2016 study into cardiovascular disease (CVD) amongst members of the NASA Apollo missions found that the CVD mortality rate in Apollo lunar astronauts was 4–5 times higher than in non-flight and Low Earth Orbit astronauts.

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