Isotretinoin is an anti-acne medication sold worldwide under the brandnames Accutane, Isoderm, Piplex, and more than 120 others.
Isotretinoin is an oral prescription medication that affects sebaceous glands and is used in the treatment of severe acne. The drug was approved by the US Food and Drug Administration (FDA) in 1982 for the treatment of severe, resistant, nodular acne that is unresponsive to conventional therapy, including systemic antibiotics. : source
At pharmacologic doses, isotretinoin inhibits sebaceous gland function and keratinization, but is mechanism of action is unknown. Several studies have shown that isotretinoin induces apoptosis (programmatic cell death) in various cells in the body.