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Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown

Fluoxetine

Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) used in the treatment of Major Depressive Disorderplugin-autotooltip__plain plugin-autotooltip_bigMajor Depressive Disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of pervasive low mood.

Current estimates are that severe depression affects around 2% of the global population at any g…
and Obsessive-Compulsive disorderplugin-autotooltip__plain plugin-autotooltip_bigObsessive-Compulsive disorder

Obsessive–compulsive disorder (OCD) is a mental disorder in which a person feels the need to perform certain routines repeatedly (called “compulsions”), or has certain thoughts repeatedly (called “obsessions”). The person is unable to cont…
etc.. It's marketed under the trade names Prozac™, Sarafem™, Fontex™ etc.

SSRIs are believed to act by inhibiting the reuptake of serotonin after being released in the brain synapses. The exact mechanism for their operation is unknown.

Quote from the prescribing information datasheet for Prozac™, from manufacturer Eli Lilly and Company.

“Although the exact mechanism of PROZAC is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin”
source

Further, the theory that manipulating serotonin levels may help in treatments is also unproven. See : PloS Medicine 2005 Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature

“…there exists no rigorous corroboration of the serotonin theory, and a significant body of contradictory evidence.”

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