Schnitlzler syndrome (SchS) is a rare* auto-inflammatory disorder characterised by a chronic urticarial rash (hives), and signs and symptoms of systemic inflammation - including fever, bone pain, joint pain, muscle pain, headache, fatigue, and loss of weight. It was first described in 1972
The cause is unknown.
* Partly because of its rareness, it is currently believed to be under-diagnosed - possibly by a factor of 3.
During the past 42 years, SchS has evolved from an elusive little-known disorder to an autoinflammatory disorder that is recognized by increasing numbers of dermatologists, rheumatologists, allergologists, hematologists and other specialists.
Source : Clin Transl Allergy. 2014; 4: 41.