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Content Guidelinesplugin-autotooltip__plain plugin-autotooltip_bigContent guidelines

Ideas for new topics are always welcomed, from experts and non-experts alike - if you're not sure if they'll be accepted by other editors, put them in the 'Proposed content' section for approval. The easiest way to create a new page is to use the

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In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

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A. Like most Wikis, the site doesn't use HTML for formatting (security reasons etc). A guide to the special syntax can be found here. Unfortunately it can be quite confusing at first - but there's now a new 'Visual E…

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• Oct 2020 : A milestone of 500 unknown articles has been reached.

• Aug 2020 : Currently (beta) testing the new 'WYSIWYG' (What You See Is What You Get) page editor. It greatly simplifies the editing process, avoiding the need to learn the…

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ME / CFS

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is a serious, long-term illness that affects many body systems. People with ME/CFS are often not able to do their usual activities. At times, ME/CFS may confine them to bed. People with ME/CFS have severe fatigue and sleep problems. ME/CFS may get worse after people with the illness try to do as much as they want or need to do. This symptom is known as post-exertional malaise (PEM). Other symptoms can include problems with thinking and concentrating, pain, and dizziness.
Researchers have not yet found what causes ME/CFS, and there are no specific laboratory tests to diagnose ME/CFS directly. Therefore, doctors need to consider the diagnosis of ME/CFS based on in-depth evaluation of a person’s symptoms and medical history. It is also important that doctors diagnose and treat any other conditions that can cause similar symptoms. Even though there is no cure for ME/CFS, some symptoms can be treated or managed.”
Source : US Centers for Disease Control and Prevention.

ME /CFS is estimated to affect around 0.2 – 0.4% of the general population.

Note: The worsening of symtoms after phycical exertion - known as Post Exertional Malaise (PEM) - is a further puzzling aspect.

“Post-exertional malaise following normal activities is unique to ME/CFS and we do not understand the biology underlying this severe and harmful feature of the disease,”
Source :US NIH


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