Kyrle disease is a relatively rare 'perforating' skin condidition which leads to the formation of multiple large (up to 1.5cm) skin papules that have central keratin plugs. It usually affects the legs, but can also erpupt in other areas.
The disease is 'associated' with, liver disease, and especially with kidney disease. The prevalence in kidney dialysis patients being around 10%
The cause is onknown.
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