Hypofrontality refers to a decreased blood flow in the frontal cortex of the human brain. Some studies rate the decease at round 5%. (example ref.) It was first discovered in 1974, and was initially assumed to be due to anti-psychotic drugs which patients were taking. But subsequent studies confirmed the findings in patients who were not undergoing treatment.
It's now known to be associated with, and
It's not known, however, if the decreased blood flow is as a result of the underlying psychological disorder, or whether it's contributing to cause the disorder. Or whether they occur alongside each other.
Currently, the exact neurophysiological mechanisms that cause hypofrontality are unknown. However, there are some possible mechanisms that are plausible and would account for many of the effects of hypofrontality
Source : Wikipedia
The dominant current theory is that there is some kind of neuronal damage which leads to poor neuro-transmission, and which then causes both the psychological problems and the hypofrontality.
Because of the possibility that hypofrontality may be causing the psychological problems, it's currently the subject of intense research - as it may be feasible to increase the bloodflow and relieve the symptoms.
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