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Content Guidelinesplugin-autotooltip__plain plugin-autotooltip_bigContent guidelines

Ideas for new topics are always welcomed, from experts and non-experts alike - if you're not sure if they'll be accepted by other editors, put them in the 'proposed_content' section for approval. The easiest way to create a new page is to use the

Registrationplugin-autotooltip__plain plugin-autotooltip_bigRegistration

At present, only registered users can create and edit articles. The registration process is very straightforward. Just click the 'Register' link at the top right of any page.

After you've registered, you'll be able to login with your password at any time…

How to edit pagesplugin-autotooltip__plain plugin-autotooltip_bigEditing pages

Once you're logged in, a grey floating 'Tool' menu at the right hand side of the screen enables access to all the main 'Content Pages' for editing. (Note: Some pages, such as the site info etc. are locked)

Like most Wikis, the site doesn't use

Importance Ratingsplugin-autotooltip__plain plugin-autotooltip_bigImportance ratings

In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

Faqplugin-autotooltip__plain plugin-autotooltip_bigFrequently Asked Questions

Q. Why the weird syntax? A. Like most Wikis, the site doesn't use HTML for formatting (security reasons etc). A guide to the special syntax can be found here. Unfortunately it can be quite confusing at first - but there's now a new 'Visual …

Newsplugin-autotooltip__plain plugin-autotooltip_bigNews

[ newest at the top ]

• Oct 2020 : A milestone of 500 unknown articles has been reached.

• Aug 2020 : Currently (beta) testing the new 'WYSIWYG' (What You See Is What You Get) page editor. It greatly simplifies the editing process, avoiding the need to learn th…

Contactsplugin-autotooltip__plain plugin-autotooltip_bigContacts

Use this form to send a message to Wikenigma . . . [ * note: all fields must be completed ]

Legalplugin-autotooltip__plain plugin-autotooltip_bigLegal

Content in general

Please note that in common with other publicly editable wikis, this website is not responsible for content posted by the public. Nevertheless, the ongoing editing process should be able to remove unsuitable content in a reasonable time. If you…


533 unknowns listed

Wikenigma supports:

plugin-autotooltip__plain plugin-autotooltip_bigDonate to Wikenigma . . .

The best way to donate is by adding new original content !

That can either be by contributing to an existing article, or by creating a new page with an as-yet-unlisted 'Known Unknown'.

Any registered user can create content.

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Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown Science

Epilepsy

“Epilepsy is a chronic noncommunicable disease of the brain that affects around 50 million people worldwide. It is characterized by recurrent seizures, which are brief episodes of involuntary movement that may involve a part of the body (partial) or the entire body (generalized) and are sometimes accompanied by loss of consciousness and control of bowel or bladder function. Seizure episodes are a result of excessive electrical discharges in a group of brain cells. Different parts of the brain can be the site of such discharges. Seizures can vary from the briefest lapses of attention or muscle jerks to severe and prolonged convulsions. Seizures can also vary in frequency, from less than 1 per year to several per day.”

[…]

Although many underlying disease mechanisms can lead to epilepsy, the cause of the disease is still unknown in about 50% of cases globally.“

Source: World Health Organization

Note: Many of the drugs which are currently used to treat epilepsy have unknown 'mechanisms of action'. e.g. Levetiracetamplugin-autotooltip__plain plugin-autotooltip_bigLevetiracetam

Levetiracetam, sold under brand names of Keppra, Elepsia, Epictal, Lenerve, Levepsy, Torleva (and many others) is a prescription-only anticonvulsant medication for epilepsy. It is used for partial onset, myoclonic, or tonic-clonic seizures. It is taken…
, Valproateplugin-autotooltip__plain plugin-autotooltip_bigValproate

"Valproate (VPA) and its valproic acid, sodium valproate, and valproate semisodium forms are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. They are useful for the prevention of seizures in those with absenc…
, Lamotrigineplugin-autotooltip__plain plugin-autotooltip_bigLamotrigine

Lamotrigine is used as an anticonvulsant and mood stabilizer. Currently prescribed in cases of epilepsy, Lennox–Gastaut syndrome and bipolar disorder. Its active biochemical pathways are not known. more info at Wikipedia

"“The action mechanisms underlying…
, Gabapentinplugin-autotooltip__plain plugin-autotooltip_bigGabapentin

Gabapentin, sold under the brandnames Gralise, Gabarone, Fanatrex, Neurontin (and mmany others) was discovered in the 1970s, and was first used as a muscle relaxant and painkiller.

In the US alone, it currently has more than 40 million prescriptions per yea…
etc.


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