Please register and log-in to create and edit pages

User Tools

    Please register and log-in to create and edit pages

Site Tools


Main Menu

Main menu
Click categories to expand

Other categories


A-Z listingplugin-autotooltip__plain plugin-autotooltip_bigA-Z listing

This is an alphabetical index of all content pages.


Also see

Importance Ratingsplugin-autotooltip__plain plugin-autotooltip_bigImportance ratings

In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (although also u…

Newsplugin-autotooltip__plain plugin-autotooltip_bigNews

[ newest at the top ]

• Mar. 2021 : Many thanks to the The British Library, which has now begun permanently archiving the contents of Wikenigma.

• Jan. 2021 : A milestone of 600 unknown articles has been reached.

• Oct. 2020 : A milestone of 500 unknown article…

Contactsplugin-autotooltip__plain plugin-autotooltip_bigContacts

Use this form to send a message to Wikenigma . . . [ * note: all fields must be completed ]

Legalplugin-autotooltip__plain plugin-autotooltip_bigLegal

Content in general

Please note that in common with other publicly editable wikis, this website is not responsible for content posted by the public. Nevertheless, the ongoing editing process should be able to remove unsuitable content in a reasonable time. If you…

Donate/Sponsorplugin-autotooltip__plain plugin-autotooltip_bigDonate to Wikenigma . . .

The best way to donate is by adding new original content !

That can either be by contributing to an existing article, or by creating a new page with an as-yet-unlisted 'Known Unknown'.

Any registered user can create content.

Registerplugin-autotooltip__plain plugin-autotooltip_bigRegistration

At present, only registered users can create and edit articles.

If you'd like to register as a contributor, please request a password.

When filling in the form, make sure you supply a valid e-mail address, as the login password will be sent to that addre…


Wikenigma supports:


Utilities
rss / xml feed
sitemap file
A-Z listing (archived)plugin-autotooltip__plain plugin-autotooltip_bigA-Z listing (archived)

This is an older, partial A-Z listing intended for search engines only.

Last updated : May 2021

For an up-to-date list see A-Z listing in the Main Menu

'Abracadabra' etymology

Acamprosate

Acrocyanosis

Acupuncture

Attention-Deficit / Hypera…

Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown Science

Enzyme catalysis

Almost all metabolic processes in living cells need enzyme catalysis in order to proceed at rates fast enough to sustain life. Although enzyme processes have been investigated for many years, and more than 5000 have been identified, the extreme complexity of the biochemistry involved has meant that the way in which a particular enzyme operates can be far from clear.

Further reading Wikipedia

A current trend involves focussing on 'electrostatic catalysis' to try and explain how the enzymes have the ultra-specific shapes they have, and which in turn influences their ultra-specific functions.

While the function of enzymes has been well-known to researchers for decades, the driving force behind it is still a hotly debated topic. Herein, we report significant evidence for electrostatics being that driving force, using a simple, computationally inexpensive, multiscale model of monoamine oxidase A and phenylethylamine.
The indispensable role of enzymes in virtually all life processes has inspired researchers for decades. The paramount role of enzymes is their catalytic function. Enzymes facilitate chemical reactions involved in biological processes to occur at significantly higher rates (and, consequently, at milder conditions) than in the plain aqueous environment. While that feature alone represents an enormous research potential, it should be stressed that enzymes are in every imaginable aspect highly complex systems. Consisting typically of thousands of atoms and including flexible domains, the structure of enzymes is governed by a sophisticated network of interactions, and the formation of the structure (folding) and its stability still remains enigmatic, despite significant research efforts on both the experimental and theoretical fronts. From a theoretical standpoint the complexity of enzymes is reflected, among the rest, in the huge conformational phase space, requiring dedicated, cutting-edge computing equipment in order to characterize even relatively simple cases of folding dynamics.

Source: Function of the Monoamine Oxidase A Enzyme Confirmed by Quantum Computations ACS Catal. 2019, 9, 2, 1231–1240

Also see Protein structuringplugin-autotooltip__plain plugin-autotooltip_bigProtein structuring

Genes set the order that amino acids (the chemical building blocks of proteins) appear in the proteins which they code for. But, working from the gene, the form which the protein's 3-D structure will take cannot as yet be predicted. The extremely co…

Importance Rating


    Share this page :

X

Dear reader : Do you have any suggestions for the site's content?

Ideas for new topics, and suggested additions / corrections for old ones, are always welcome.

If you have skills or interests in a particular field, and have suggestions for Wikenigma, get in touch !


Or, if you'd like to become a regular contributor . . . request a login password. Registered users can edit the entire content of the site, and also create new pages.

( The 'Notes for contributors' section in the main menu has further information and guidelines etc.)

Show another (random) page

DOKUWIKI IMPLEMENTATION DESIGN BY UNIV.ORG.UK MAY 2021