====== Nimesulide ======

//Nimesulide// is classed as a fast-acting non-steroidal anti-inflammatory drug (NSAID). It's sold widely across Europe, Latin America and Asia as a prescription-only anti-inflammatory - but not in the US, due to concerns about liver damage.

It's marketed under the brand names //Coxta, Eskaflam, Octaprin, Nimside, Nise, Nilsid, Drexel, Donulide, Nimutab, Novolid, Relmex //and many others [[https://en.wikipedia.org/wiki/Nimesulide#Brand_names|ref]]

It was discovered in 1971, but its mechanism of action has not yet been properly described.

>Nimesulide effects are unique and not shared with other selective COX-2 inhibitors. On the inflammatory process, the efficacy of nimesulide is dependent upon a wide spectrum of actions, due to the combination of effects on immune and non–immune cells, resident cells and extracellular matrix with a biochemical mechanism that has not been elucidated at all, but there is much evidence that it goes beyond COX-2 inhibition\\ \\ See [[https://www.sciencedirect.com/science/article/abs/pii/S001429991930069X?via%3Dihub|The relatively selective cyclooxygenase-2 inhibitor nimesulide: What’s going on?]]// European Journal of Pharmacology,// Volume 848, 5 April 2019, Pages 105-111