====== Acne ======

Acne is an extremely common skin condition which mainly affects the adolescent population (currently estimated at over 90%).

Despite very intensive research over many decades, a detailed explanation of what triggers and maintains the condition is still lacking.

>Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Although early colonisation with P acnes and family history might have important roles in the disease, __exactly what triggers acne and how treatment affects the course of the disease remain unclear.__\\ \\ Source :{{:oa_padlock_grn.png?16}}[[https://www.cyberderm.net/secure-uploads/attachments/ckobm0zav00d1r42bkrna91av-4-1-1-acne-williams-2012-review.pdf|Seminar, The Lancet]] , Vol 379.

There are many factors which are known to increase the risk of developing acne - including :

  * hormonal changes
  * high humidity
  * dust exposure
  * high ambient temperature
  * skin mites
  * bacteria
  * microbiome changes
  * diet
  * genetic factors
  * stress
  * sunlight exposure
  * pollutants

It's still not known, however, why many individuals are badly affected, and others have no symptoms.