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Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown

Psychedelic drugs

Psychedelics are a hallucinogenic class of psychoactive drug which have the primary effect of triggering non-ordinary states of consciousness and psychedelic experiences.

Many of the known psychedelic substances have been found to bind to and activate the brain's serotonin 5-HT2A receptors. ( see Wikipedia )

Although it has been experimentally found that activating the 5-HT2A receptors leads to a marked increase in spontaneous (glutamate-mediated) synaptic activity in the prefrontal cortex, exactly how and why this leads to psychedelia remains unknown.

Further reading : Proceedings of the National Academy of Sciences

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