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Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown


Isotretinoin (13-cis-retinoic acid) is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It's sold under various brand names, including : Accutane, Roaccutane, Rizuderm.

While isotretinoin is currently the most effective agent for patients with moderate-to-severe acne, the drug’s potential to induce human congenital abnormalities, and its wide range of side-effects, is driving research to find replacements. This is hampered because :

“Isotretinoin's exact mechanism of action is unknown, but several studies have shown that isotretinoin induces apoptosis (programmatic cell death) in various cells in the body.”

Further info : Wikipedia

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