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Wikenigma - an Encyclopedia of Unknowns Wikenigma - an Encyclopedia of the Unknown Wikenigma - an Encyclopaedia of Unknowns Wikenigma - an Encyclopaedia of the Unknown

Migraine

“Chronic migraine has a great detrimental influence on a patient’s life, with a severe impact on socioeconomic functioning and quality of life. Chronic migraine affects 1–2% of the general population, and about 8% of patients with migraine; it usually develops from episodic migraine at an annual conversion rate of about 3%.”

However, despite many decades of intensive research :

“The physiological mechanisms that underlie development of chronic migraine are not entirely understood.”
source: Chronic migraine: risk factors, mechanisms and treatment Nature Reviews Neurology 12, 455–464 (2016)

Or as the Wikipedia page more directly puts it : The underlying causes of migraines are unknown

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