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Content Guidelinesplugin-autotooltip__plain plugin-autotooltip_bigContent guidelines

Ideas for new topics are always welcomed, from experts and non-experts alike - if you're not sure if they'll be accepted by other editors, put them in the 'proposed_content' section for approval. The easiest way to create a new page is to use the

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At present, only registered users can create and edit articles. The registration process is very straightforward. Just click the 'Register' link at the top right of any page.

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How to edit pagesplugin-autotooltip__plain plugin-autotooltip_bigEditing pages

Once you're logged in, a grey floating 'Tool' menu at the right hand side of the screen enables access to all the main 'Content Pages' for editing. (Note: Some pages, such as the site info etc. are locked)

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In a departure from the usual Wiki format, Wikenigma assigns 'Importance Ratings' to some the page pages.

The idea is to separate articles which are considered (by the editors) to cover exceptionally important unknown issues from those which (althou…

Faqplugin-autotooltip__plain plugin-autotooltip_bigFrequently Asked Questions

Q. Why the weird syntax? A. Like most Wikis, the site doesn't use HTML for formatting (security reasons etc). A guide to the special syntax can be found here. Unfortunately it can be quite confusing at first - but there's now a new 'Visual …

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• Aug 2020 : Currently (beta) testing the new 'WYSIWYG' (What You See Is What You Get) page editor. It greatly simplifies the editing process, avoiding the need to learn the Wiki syntax. (Note: it's currently not 100% stable)

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500 unknowns listed

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Caloric restriction

“Calorie restriction, or caloric restriction, or energy restriction, is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. 'Low' can be defined relative to the subject's previous intake before intentionally restricting calories, or relative to an average person of similar body type. In a number of species, including yeast, fish, rodents and dogs, calorie restriction without malnutrition has been shown to slow the biological aging process, resulting in longer maintenance of youthful health and an increase in both median and maximum lifespan.”
Source: Wikipedia

Detailed experimental research on caloric restriction has been going on for over 70 years, but “the mechanism underlying this phenomenon is still unknown.”
Source: Caloric Restriction and Aging: Studies in Mice and Monkeys

Theories regarding possible mechanisms include the effects of:
• reduced core body temperature
• reduced cellular divisions
• lower metabolic rates
• reduced production of free radicals
• reduced DNA damage
• hormesis (any process in a cell or organism that exhibits a biphasic response to exposure to increasing amounts of a substance or condition)


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